Kai Chen Ph.D. in Chinese Medicine

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Viral Hepatitis

Introduction  

Viral hepatitis is inflammation of liver caused by virus infectious.  There are five forms of hepatitis.  Hepatitis A: HAV is highly contagious and is usually transmitted by fecal-oral route.  Hepatitis B:  HBV is transmitted by the direct exchange of contaminated blood, also human secretions and feces.  The incubation period ranges from 45-180 days, and the onset of acute disease is generally insidious.  Most acute HBV infections in adults result in complete recovery.  However, approximately 30%-90% of young children and 2%-10% of adults who are infected with HBV develop chronic infection.  Hepatitis C:  HCV is often transmitted through transfused blood from asymptomatic donors.  About 30% to 40% of persons with acute infection develop symptomatic illness and 20% to 30% have jaundice. Chronic liver disease develops in about 70% of persons who become infected with HCV and nearly all (85%-100%) persons with acute HCV infection become persistently infected; these persons are at risk for developing cirrhosis and liver cancer. Hepatitis D (Delta): HDV infection can be acquired either as a coinfection with HBV or as a superinfection of persons with chronic HBV infection. Persons with HBV-HDV coinfection may have more severe acute disease and a higher risk of fulminate hepatitis (2%-20%) compared with those infected with HBV alone; however, chronic HBV infection appears to occur less frequently in persons with HBV-HDV coinfection.  Hepatitis E:  It is transmitted enterically, like HAV.  Typical clinical signs and symptoms of acute hepatitis  are similar for different types of viral hepatitis.  In the prodromal (preicteric) stage, common symptoms are fatigue, malaise, arthralgia, myalgia, nausea and vomiting, and mild fever.  In jaundice stage, symptoms include jaundice, abdominal pain anorexia, dark urine, fever, hepatomegaly, malaise, nausea, and vomiting. Other less common symptoms include pruritus and urticarial rash. During the recovery (posticteric), most of patient’s symptoms decrease or subside.  Hepatitis A is acute and with good prognosis. In this secession hepatitis B is mainly discussed.  The symptoms and signs in chronic hepatitis are varied depending on the inflammations conditions, may be fatigue, abdominal distension, poor appetite, right side hypochondria pain, etc. 

TCM etiology and pathology  

In TCM, there is no similar name as hepatitis.  The main symptoms of hepatitis are jaundice, hypochondria pain, abdominal fullness and loss appetite, the hepatitis TCM illness may be Huangdan (jaundice), or Xietong (hypochondria pain), or Fuzhang (abdominal fullness), or Nadai (loss appetite), etc. The cause mainly is pathogenic factors, mainly damp-heat or heat-toxin invading Liver-gallbladder. Others include dirt disorder, such as in a long period, overeating greasy food or spicy food, over-drinking alcohol, Liver qi stagnation, blood stasis,  Liver yin deficiency, etc.  Generally speaking, the acute hepatitis often is excessive, mainly pathogenic factors invading, and the chronic hepatitis is mixed with excessive and deficiency, the formal is stagnated pathogenic factors and that cause qi and blood stasis, the later is yin and qi deficiency.

TCM differentiation and treatment

1. Acute hepatitis

Clinical manifestation: Jaundice, bright yellow color, fever, nausea, vomiting, poor appetite, abdominal fullness, white stools, red tongue with yellow greasy fur, rapid pulse  

Treatment principle: Dispersing hear and resolving dampness

Herbal prescription: Modified Yin Chen Hao Tang

Acupuncture: Danshu (BL19), Zhiyang (DU9), Yanglingquan (GB34), Yinlingquan (SP9), Taichong (Liv3)  

2. Chronic hepatitis

2.1 Disharmonized liver-spleen

Clinical manifestation: Hypochondria distension pain, abdominal fullness, loss appetite, nausea, or fatigue, or vomiting and diarrhea, big tongue body with white greasy fur or yellow greasy fur, taut and slippery pulse 

Treatment principle: Harmonizing liver-spleen

Herbal prescription: Modified Chai Hu Shu Gan San

Acupuncture: Ganshu (BL18), Xingjian (Liv2), Pishu (BL20), Yanglingquan (GB34), Zusanli (ST36), Fenglong (ST40)

2.2 Blood stasis 

Clinical manifestation: Hypochondria stabbing and sharp pain, touchable enlarged and harder liver, dark and pale complexion, loss appetite, nausea, vomiting, fatigue, purple tongue, deep and weak pulse  

Treatment principle: Promoting blood circulation to remove stasis, softening the masses

Herbal Prescription: Modified Gexia Zhuyu Tang

Acupuncture: Dabao (SP21), Zhigou (SJ6), Taichong (Liv3), Geshu (BL17), Sanyinjiao (SP6)

2.3 Liver yin deficiency

Clinical manifestation: Hypochondria dull pain, emaciated, afternoon or at night low fever, dizziness, poor appetite, fatigue, dark red complexion, low back and knee weakness and soreness, impotence or menstruation disorders, red narrow tongue body with yellow fur or without fur, deep and weak pulse 

Treatment principle: Tonifying liver yin

Herbal prescription: Modified Yinguan Jian

Acupuncture: Ganshu (Bl18), Taichong (Liv3), Taixi (KD3), Sanyinjiao (SP6), Zusanli

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